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Biomedical science now stands on the threshold of a new and uncharted era of discovery which promises to revolutionize the treatment of facial defects. Advances in stem cell biology, gene therapy and nanotechnology are increasing the likelihood that in the not-too-distant future we will be repairing the devastation caused by birth defects, cancer, or trauma by regenerating skin, bone, and soft tissue. The impact of such an achievement will be remarkable and far-reaching.